| 1 |
Erlotinib |
Tarceva, RG-1415, CP-358774, OSI-774, Ro-508231, R-1415 |
EGFR |
EGFR signaling |
59 |
0 |
| 3 |
Rapamycin |
AY-22989, Sirolimus, WY-090217, Torisel, Rapamune |
MTORC1 |
PI3K/MTOR signaling |
0 |
2 |
| 5 |
Sunitinib |
Sutent, Sunitinib Malate, SU-11248 |
PDGFR, KIT, VEGFR, FLT3, RET, CSF1R |
RTK signaling |
7 |
1 |
| 6 |
PHA-665752 |
PHA665752, PHA 665752 |
MET |
RTK signaling |
0 |
0 |
| 9 |
MG-132 |
LLL cpd, MG 132, MG132 |
Proteasome, CAPN1 |
Protein stability and degradation |
0 |
0 |
| 11 |
Paclitaxel |
BMS-181339-01, Taxol, Onxol, Paxene, Praxel, Abraxane |
Microtubule stabiliser |
Mitosis |
0 |
0 |
| 17 |
Cyclopamine |
NA |
SMO |
Other |
34 |
5 |
| 29 |
AZ628 |
AZ-628, AZ 628 |
BRAF |
ERK MAPK signaling |
15 |
6 |
| 30 |
Sorafenib |
Nexavar, 284461-73-0, BAY 43-9006 |
PDGFR, KIT, VEGFR, RAF |
RTK signaling |
1 |
1 |
| 32 |
Tozasertib |
MK 0457,MK-0457,MK-045, VX-680 VX 680 VX-68 |
AURKA, AURKB, AURKC, others |
Mitosis |
5 |
1 |
| 34 |
Imatinib |
Gleevec, STI-571 |
ABL, KIT, PDGFR |
Other, kinases |
92 |
4 |
| 35 |
NVP-TAE684 |
NVP-TAE 684, TAE684, TAE-684 |
ALK |
RTK signaling |
0 |
0 |
| 37 |
Crizotinib |
Xalkori, PF2341066, PF-2341066, PF 2341066 |
MET, ALK, ROS1 |
RTK signaling |
42 |
38 |
| 38 |
Saracatinib |
AZD0530, AZD-0530, AZ-10353926 |
ABL, SRC |
Other, kinases |
4 |
1 |
| 41 |
S-Trityl-L-cysteine |
NSC 83265, Tritylcysteine |
KIF11 |
Mitosis |
0 |
0 |
| 45 |
Z-LLNle-CHO |
Z-L-Norleucine-CHO, Gamma-Secretase Inhibitor 1 |
gamma-secretase |
Other |
2 |
1 |
| 51 |
Dasatinib |
BMS-354825-03, BMS-354825, Sprycel |
ABL, SRC, Ephrins, PDGFR, KIT |
RTK signaling |
36 |
1 |
| 52 |
GNF-2 |
KIN001-013 |
BCR-ABL |
ABL signaling |
0 |
0 |
| 53 |
CGP-60474 |
KIN001-019, CGP60474, CGP 60474 |
CDK1,CDK2,CDK5,CDK7,CDK9, PKC |
Cell cycle |
1 |
0 |
| 54 |
CGP-082996 |
CINK4, KIN001-021 |
CDK4 |
Cell cycle |
1 |
6 |
| 55 |
A-770041 |
KIN001-111 |
LCK, FYN |
Other, kinases |
4 |
1 |
| 56 |
WH-4-023 |
KIN001-112 |
SRC, LCK |
Other, kinases |
4 |
0 |
| 59 |
WZ-1-84 |
KIN001-123 |
BMX |
Other, kinases |
12 |
4 |
| 60 |
BI-2536 |
NA |
PLK1, PLK2, PLK3 |
Cell cycle |
0 |
0 |
| 62 |
BMS-536924 |
BMS 536924 |
IGF1R, IR |
IGF1R signaling |
0 |
0 |
| 63 |
BMS-509744 |
KIN001-127, ITK inhibitor |
ITK |
Other, kinases |
0 |
11 |
| 64 |
CMK |
KIN001-128 |
RSK2 |
Other, kinases |
1 |
2 |
| 71 |
Pyrimethamine |
Daraprim, Chloridine |
Dihydrofolate reductase (DHFR) |
Other |
0 |
9 |
| 83 |
JW-7-52-1 |
NA |
MTOR |
PI3K/MTOR signaling |
0 |
4 |
| 86 |
A-443654 |
KIN001-139 |
AKT1, AKT2, AKT3 |
PI3K/MTOR signaling |
0 |
0 |
| 87 |
GW843682X |
GW843682X (AN-13) |
PLK1 |
Cell cycle |
0 |
1 |
| 88 |
Entinostat |
MS-275 |
HDAC1, HDAC3 |
Chromatin histone acetylation |
0 |
0 |
| 89 |
Parthenolide |
NA |
HDAC1 |
Chromatin histone acetylation |
5 |
1 |
| 91 |
GSK319347A |
KIN001-135, IKK-3 inhibitor |
IKK |
Other, kinases |
0 |
0 |
| 94 |
TGX221 |
TGX-221, Tgx 221 |
PI3Kbeta |
PI3K/MTOR signaling |
58 |
2 |
| 104 |
Bortezomib |
PS-341, LDP-341, Velcade |
Proteasome |
Protein stability and degradation |
0 |
15 |
| 106 |
XMD8-85 |
ERK5-IN-1 |
ERK5, BET |
Other |
2 |
1 |
| 110 |
Seliciclib |
Roscovitine, CYC-202, AL-39256 |
CDK2, CDK7, CDK9 |
Cell cycle |
4 |
4 |
| 111 |
Salubrinal |
EIF-2alpha Inhibitor |
EIF2A |
Other |
3 |
1 |
| 119 |
Lapatinib |
Tykerb, Tyverb |
EGFR, ERBB2 |
RTK signaling |
87 |
5 |
| 127 |
GSK269962A |
GSK 269962A |
ROCK1, ROCK2 |
Cytoskeleton |
4 |
0 |
| 133 |
Doxorubicin |
Doxil, Rubex, Adriamycin, Adriablastin, Doxorubicine |
Anthracycline |
DNA replication |
0 |
8 |
| 134 |
Etoposide |
Etopophos, Vepesid, Eposin, VP-16 |
TOP2 |
DNA replication |
0 |
0 |
| 135 |
Gemcitabine |
Gemzar, LY-188011 |
Pyrimidine antimetabolite |
DNA replication |
0 |
4 |
| 136 |
Mitomycin-C |
Mytozytrex, NSC-26980, MMC, Mitosol, Mitozytrex |
DNA crosslinker |
DNA replication |
0 |
5 |
| 140 |
Vinorelbine |
vinorelbine tartrate, Navelbine, Exelbine |
Microtubule destabiliser |
Mitosis |
0 |
3 |
| 147 |
NSC-87877 |
NSC 87877 |
SHP-1 (PTPN6), SHP-2 (PTPN11) |
Other |
9 |
61 |
| 150 |
Bicalutamide |
ICI-176334, Casodex, Cosudex, ICI 176334 |
AR |
Hormone-related |
0 |
0 |
| 151 |
QS11 |
944328-88-5 |
ARFGAP1 |
Other |
0 |
22 |
| 152 |
CP466722 |
CP-466722, CP 466722, 1080622-86-1 |
ATM |
Genome integrity |
20 |
0 |
| 153 |
Midostaurin |
PKC412, benzoylstaurosporine, CGP-41251 |
PKC, PPK, FLT1, c-FGR, others |
Other |
0 |
0 |
| 154 |
CHIR-99021 |
CT 99021, CHIR99021, CHIR 99021 |
GSK3A, GSK3B |
WNT signaling |
22 |
4 |
| 155 |
Ponatinib |
AP24534, AP-24534, KIN001-192, Iclusig |
ABL, PDGFRA, VEGFR2, FGFR1, SRC, TIE2, FLT3 |
Other, kinases |
43 |
12 |
| 156 |
AZD6482 |
AZD 6482, AZD-6482, AK-55409 |
PI3Kbeta |
PI3K/MTOR signaling |
0 |
2 |
| 157 |
JNK-9L |
KIN001-204, JNK inhibitor 9l |
JNK2, JNK3 |
JNK and p38 signaling |
0 |
15 |
| 158 |
PF-562271 |
PF-00562271 |
FAK, FAK2 |
Cytoskeleton |
0 |
18 |
| 159 |
HG6-64-1 |
KIN001-206 |
BRAF |
ERK MAPK signaling |
0 |
3 |
| 163 |
JQ1 |
JQ-1, (+)-JQ-1 |
BRD2, BRD3, BRD4, BRDT |
Chromatin other |
0 |
1 |
| 164 |
JQ12 |
NA |
HDAC1, HDAC2 |
Chromatin histone acetylation |
0 |
1 |
| 165 |
DMOG |
Dimethyloxalylglcine |
HIF-PH |
Metabolism |
0 |
42 |
| 166 |
FTI-277 |
NA |
Farnesyl-transferase (FNTA) |
Other |
0 |
0 |
| 167 |
OSU-03012 |
AR-12, OSU 03012, OSU03012, PDK1 inhibitor AR-12 |
PDK1 (PDPK1) |
Metabolism |
0 |
1 |
| 170 |
Shikonin |
Anchusin |
not defined |
Other |
0 |
110 |
| 171 |
AKT inhibitor VIII |
Akti-1/2, KIN001-102 |
AKT1, AKT2, AKT3 |
PI3K/MTOR signaling |
2 |
21 |
| 172 |
Embelin |
Emberine, Embelic acid |
XIAP |
Apoptosis regulation |
0 |
0 |
| 173 |
FH535 |
NA |
PPARgamma, PPARdelta |
Other |
0 |
7 |
| 175 |
PAC-1 |
GTPL5238 |
Procaspase-3, Procaspase-7 |
Apoptosis regulation |
81 |
48 |
| 176 |
IPA-3 |
IPA 3 |
PAK1 |
Cytoskeleton |
9 |
1 |
| 177 |
GSK650394 |
GSK-650394, GSK 650394 |
SGK2, SGK3 |
Other, kinases |
0 |
23 |
| 178 |
BAY-61-3606 |
Syk Inhibitor, BAY-613606 |
SYK |
Other, kinases |
0 |
13 |
| 179 |
5-Fluorouracil |
5-FU |
Antimetabolite (DNA & RNA) |
Other |
22 |
41 |
| 180 |
Thapsigargin |
Octanoic acid |
SERCA |
Other |
0 |
10 |
| 182 |
Obatoclax Mesylate |
GX15-070MS, Obatoclax, GX15-070 |
BCL2, BCL-XL, BCL-W, MCL1 |
Apoptosis regulation |
0 |
76 |
| 184 |
BMS-754807 |
BMS754807, BMS 754807 |
IGF1R, IR |
RTK signaling |
0 |
0 |
| 185 |
Linsitinib |
OSI-906, ASP-7487 |
IGF1R |
IGF1R signaling |
1 |
4 |
| 186 |
Bexarotene |
LG-100069, Targretin, Targret, Targrexin, Targretyn, Bexarotenum |
Retinioic X receptor (RXR) agonist |
Other |
3 |
5 |
| 190 |
Bleomycin |
NA |
dsDNA break induction |
DNA replication |
0 |
7 |
| 192 |
LFM-A13 |
DDE-28 |
BTK |
Other, kinases |
0 |
0 |
| 193 |
GW-2580 |
GX2580, CFMS receptor tyrosine kinase inhibitor |
CSF1R |
RTK signaling |
0 |
0 |
| 194 |
Luminespib |
AUY922, VER-52296,NVP-AUY922, AUY |
HSP90 |
Protein stability and degradation |
0 |
8 |
| 196 |
Phenformin |
DBI |
Biguanide agent |
Other |
0 |
1 |
| 197 |
Bryostatin 1 |
Bryostatin |
PKC |
Other |
7 |
15 |
| 199 |
Pazopanib |
Votrient |
CSF1R, KIT, PDGFRA, PDGFRB |
RTK signaling |
0 |
3 |
| 200 |
Dacinostat |
NVP-LAQ824, LAQ824 |
HDAC1 |
Chromatin histone acetylation |
0 |
37 |
| 201 |
Epothilone B |
Patupilone, EpoB, EPO906, GNF-PF-193 |
Microtubule stabiliser |
Mitosis |
0 |
3 |
| 202 |
GSK1904529A |
GSK-1904529A, GSK 1904529A |
IGF1R, IR |
RTK signaling |
0 |
0 |
| 203 |
BMS-345541 |
BMS345541, IKK Inhibitor 3 |
IKK1, IKK2 |
Other, kinases |
56 |
8 |
| 204 |
Tipifarnib |
Zarnestra |
Farnesyl-transferase (FNTA) |
Other |
0 |
6 |
| 205 |
Avagacestat |
BMS-708163, BMS 708163 |
Amyloid beta20, Amyloid beta40 |
Other |
0 |
0 |
| 206 |
Ruxolitinib |
INCB-18424, Ruxolitinib Phosphate, Jakafi |
JAK1, JAK2 |
Other, kinases |
140 |
76 |
| 207 |
AS601245 |
NA |
JNK1, JNK2, JNK2 |
JNK and p38 signaling |
0 |
1 |
| 208 |
Ispinesib Mesylate |
SB-715992 |
KSP |
Mitosis |
0 |
10 |
| 211 |
TL-2-105 |
NA |
not defined |
Other |
17 |
43 |
| 219 |
AT-7519 |
AT7519 |
CDK1, CDK2, CDK4, CDK6, CDK9 |
Cell cycle |
21 |
4 |
| 221 |
TAK-715 |
KIN001-201, TAK 715 |
p38alpha, p38beta |
JNK and p38 signaling |
25 |
74 |
| 222 |
BX-912 |
NA |
PDK1 (PDPK1) |
Metabolism |
91 |
5 |
| 223 |
ZSTK474 |
KIN001-167, ZSTK-474, ZSTK 474 |
PI3K (class 1) |
PI3K/MTOR signaling |
18 |
2 |
| 224 |
AS605240 |
KIN001-173, AS-605240 |
PI3Kgamma |
PI3K/MTOR signaling |
5 |
1 |
| 225 |
Genentech Cpd 10 |
NA |
AURKA, AURKB |
Mitosis |
17 |
0 |
| 226 |
GSK1070916 |
GSK-1070916 |
AURKA, AURKC |
Mitosis |
35 |
0 |
| 228 |
AKT inhibitor VIII |
Akti-1/2, KIN001-102 |
AKT1, AKT2, AKT3 |
PI3K/MTOR signaling |
76 |
27 |
| 229 |
Enzastaurin |
LY317615 |
PKCB |
Other, kinases |
0 |
7 |
| 230 |
GSK429286A |
NA |
ROCK1, ROCK2 |
Cytoskeleton |
7 |
12 |
| 231 |
FMK |
KIN001-242 |
RSK |
Other, kinases |
76 |
103 |
| 235 |
QL-XII-47 |
NA |
BTK, BMX |
Other, kinases |
0 |
0 |
| 236 |
IC-87114 |
NA |
PI3Kdelta |
PI3K/MTOR signaling |
171 |
10 |
| 238 |
Idelalisib |
CAL-101, Zydelig |
PI3Kdelta |
PI3K/MTOR signaling |
87 |
12 |
| 245 |
UNC0638 |
UNC-0638, UNC 0683 |
G9a and GLP methyltransferases |
Chromatin histone methylation |
31 |
1 |
| 249 |
Cabozantinib |
BMS-907351, XL-184, Cometriq |
VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, TIE2,AXL |
RTK signaling |
20 |
5 |
| 252 |
WZ3105 |
NA |
SRC, ROCK2, NTRK2, FLT3, IRAK1, others |
Other |
28 |
3 |
| 253 |
XMD14-99 |
NA |
ALK, CDK7, LTK, others |
Other, kinases |
103 |
15 |
| 254 |
Quizartinib |
AC220, AC 220, AC-220, Asp-2689 |
FLT3 |
RTK signaling |
103 |
4 |
| 255 |
CP724714 |
CP-724714 |
ERBB2 |
RTK signaling |
8 |
16 |
| 256 |
JW-7-24-1 |
NA |
LCK |
Other, kinases |
9 |
2 |
| 257 |
NPK76-II-72-1 |
NA |
PLK3 |
Cell cycle |
106 |
16 |
| 258 |
STF-62247 |
STF62247 |
Autophagy inducer |
Other |
20 |
48 |
| 260 |
NG-25 |
NG25 |
TAK1, MAP4K2 |
Other, kinases |
46 |
2 |
| 261 |
TL-1-85 |
NA |
TAK |
Other, kinases |
69 |
9 |
| 262 |
VX-11e |
VX11e, VX11e |
ERK2 |
ERK MAPK signaling |
0 |
17 |
| 263 |
FR-180204 |
FR 180204, FR180204, ERK Inhibitor II |
ERK1, ERK2 |
ERK MAPK signaling |
131 |
4 |
| 264 |
ACY-1215 |
NA |
HDAC6 |
Chromatin histone acetylation |
50 |
4 |
| 265 |
Tubastatin A |
NA |
HDAC1, HDAC6, HDAC8 |
Chromatin histone acetylation |
3 |
19 |
| 266 |
Zibotentan |
ZD4054, ZD-4054 |
Endothelin-1 receptor (EDNRA) |
Other |
0 |
0 |
| 268 |
Sepantronium bromide |
YM155, YM-155, YM 155 |
BIRC5 |
Apoptosis regulation |
0 |
19 |
| 269 |
NSC-207895 |
XI-006, NSC207895 |
MDM4 |
p53 pathway |
0 |
6 |
| 271 |
VNLG/124 |
HDAC inhibitor XV |
HDAC,RAR |
Chromatin histone acetylation |
102 |
6 |
| 272 |
AR-42 |
HDAC-42, AR 42, AR42 |
HDAC1 |
Chromatin histone acetylation |
20 |
38 |
| 273 |
CUDC-101 |
CUDC 101 |
HDAC1-10, EGFR, ERBB2 |
Other |
23 |
5 |
| 274 |
Belinostat |
PXD101, PXD-101 |
HDAC1 |
Chromatin histone acetylation |
16 |
19 |
| 275 |
I-BET-762 |
GSK525762A |
BRD2, BRD3, BRD4 |
Chromatin other |
89 |
13 |
| 276 |
CAY10603 |
NA |
HDAC1, HDAC6 |
Chromatin histone acetylation |
35 |
14 |
| 277 |
Linifanib |
ABT-869, ABT 869 |
VEGFR1, VEGFR2, VEGFR3, CSF1R, FLT3, KIT |
RTK signaling |
154 |
4 |
| 279 |
BIX02189 |
BIX 02189 |
MEK5, ERK5 |
ERK MAPK signaling |
51 |
43 |
| 281 |
Alectinib |
CH5424802, CH 542802, Alecensa |
ALK |
RTK signaling |
8 |
9 |
| 282 |
Pelitinib |
EKB-569, EKB 569 |
EGFR |
EGFR signaling |
0 |
1 |
| 283 |
Omipalisib |
GSK2126458, GSK-2126458, EX-8678, GSK458 |
PI3K (class 1), MTORC1, MTORC2 |
PI3K/MTOR signaling |
2 |
2 |
| 284 |
JNJ38877605 |
NA |
MET |
RTK signaling |
0 |
8 |
| 285 |
SU11274 |
NA |
MET |
RTK signaling |
6 |
31 |
| 286 |
KIN001-236 |
NA |
Angiopoietin-1 receptor |
RTK signaling |
123 |
52 |
| 287 |
KIN001-244 |
PDK1 inhibitor 7 |
PDK1 (PDPK1) |
Metabolism |
34 |
8 |
| 288 |
WHI-P97 |
AC1L1GQE, KIN001-055 |
JAK3 |
Other, kinases |
3 |
22 |
| 289 |
KIN001-042 |
NA |
GSK3B |
WNT signaling |
0 |
0 |
| 290 |
KIN001-260 |
Bayer IKKb inhibitor, ACHP |
IKKB |
Other, kinases |
16 |
6 |
| 291 |
KIN001-266 |
NA |
MAP3K8 |
ERK MAPK signaling |
0 |
2 |
| 292 |
Masitinib |
AB1010, Masivet |
KIT, PDGFRA, PDGFRB |
RTK signaling |
12 |
21 |
| 293 |
Amuvatinib |
MP470, MP 470, MP-470 |
KIT, PDGFRA, FLT3 |
RTK signaling |
0 |
2 |
| 294 |
MPS-1-IN-1 |
NA |
MPS1 |
Mitosis |
0 |
10 |
| 295 |
NVP-BHG712 |
BHG712 |
EPHB4 |
RTK signaling |
42 |
15 |
| 298 |
OSI-930 |
OSI 930 OSI930 |
KIT |
RTK signaling |
84 |
28 |
| 299 |
OSI-027 |
A-1065-5 |
MTORC1, MTORC2 |
PI3K/MTOR signaling |
9 |
2 |
| 300 |
CX-5461 |
CX5461, CX 5461 |
RNA Polymerase 1 |
Other |
46 |
19 |
| 301 |
PHA-793887 |
PHA793887, PHA 793887 |
CDK2, CDK7, CDK5 |
Cell cycle |
105 |
8 |
| 302 |
PI-103 |
PI-103, PI103, PI 103 |
PI3Kalpha, DAPK3, CLK4, PIM3, HIPK2 |
Other, kinases |
34 |
2 |
| 303 |
PIK-93 |
PIK 93, PIK93 |
PI3Kgamma |
PI3K/MTOR signaling |
24 |
4 |
| 304 |
SB52334 |
SB-52334, SB 52334 |
ALK5 |
Other, kinases |
4 |
2 |
| 305 |
TPCA-1 |
NA |
IKK2 |
Other, kinases |
85 |
4 |
| 306 |
Fedratinib |
TG101348, TG-101348, SAR302503, SAR-302503 |
JAK2 |
Other, kinases |
68 |
2 |
| 308 |
Foretinib |
GSK1363089, XL-880, EXEL-2880, GSK089 |
MET, KDR, TIE2, VEGFR3/FLT4, RON, PDGFR, FGFR1, EG |
RTK signaling |
3 |
19 |
| 309 |
Y-39983 |
NA |
ROCK |
Cytoskeleton |
7 |
22 |
| 310 |
YM201636 |
YM-201636, YM 201636 |
PIKFYVE |
PI3K/MTOR signaling |
17 |
15 |
| 312 |
Tivozanib |
AV-951, AV 951, KRN-951, KIL8951, ASP-4130 |
VEGFR1, VEGFR2, VEGFR3 |
RTK signaling |
148 |
2 |
| 317 |
WYE-125132 |
NA |
mTOR |
PI3K/MTOR signaling |
3 |
6 |
| 326 |
GSK690693 |
GSK 690693, GSK-690693 |
AKT1, AKT2, AKT3 |
PI3K/MTOR signaling |
33 |
120 |
| 328 |
SNX-2112 |
SNX 2112 |
HSP90 |
Protein stability and degradation |
12 |
0 |
| 329 |
QL-XI-92 |
NA |
DDR1 |
Cytoskeleton |
38 |
4 |
| 330 |
XMD13-2 |
NA |
RIPK1 |
Apoptosis regulation |
14 |
19 |
| 331 |
QL-X-138 |
NA |
BTK |
Other, kinases |
8 |
2 |
| 332 |
XMD15-27 |
NA |
CAMK2 |
Other, kinases |
0 |
0 |
| 333 |
T0901317 |
TO-901317, TO901317 |
LXR, FXR |
Other |
107 |
16 |
| 341 |
Selisistat |
EX-527, EX 527 |
SIRT1 |
Chromatin histone acetylation |
0 |
0 |
| 342 |
Tenovin-6 |
NA |
SIRT |
Chromatin histone acetylation |
3 |
1 |
| 344 |
THZ-2-49 |
NA |
CDK9 |
Cell cycle |
0 |
0 |
| 345 |
KIN001-270 |
CDK9 inhibitor, CDK9-IN-1 |
CDK9 |
Cell cycle |
129 |
5 |
| 346 |
THZ-2-102-1 |
NA |
CDK7 |
Cell cycle |
26 |
12 |
| 356 |
AT7867 |
NA |
AKT |
PI3K/MTOR signaling |
2 |
6 |
| 362 |
CI-1033 |
NA |
EGFR, ERBB2, ERBB4 |
RTK signaling |
0 |
1 |
| 363 |
PF-00299804 |
NA |
EGFR, ERBB2, ERBB4 |
RTK signaling |
0 |
2 |
| 366 |
TWS119 |
NA |
GSK3 |
WNT signaling |
0 |
1 |
| 371 |
Torin 2 |
NA |
mTOR |
PI3K/MTOR signaling |
3 |
1 |
| 372 |
Pilaralisib |
XL-147 |
PI3K |
PI3K/MTOR signaling |
0 |
3 |
| 374 |
GSK1059615 |
NA |
PI3K |
PI3K/MTOR signaling |
0 |
8 |
| 375 |
Voxtalisib |
XL-765, SAR245409 |
PI3K (class 1), DNAPK, MTOR |
PI3K/MTOR signaling |
4 |
1 |
| 376 |
Brivanib, BMS-540215 |
NA |
VEGFR, PDGFR |
RTK signaling |
4 |
9 |
| 380 |
BIBF-1120 |
NA |
VEGFR, PDGFR, FGFR |
RTK signaling |
4 |
1 |
| 381 |
AST-1306 |
NA |
EGFR, ERBB4 |
RTK signaling |
0 |
6 |
| 382 |
Apitolisib |
GDC0980 |
mTOR, PI3K |
PI3K/MTOR signaling |
0 |
6 |
| 406 |
LIMK1 inhibitor BMS4 |
NA |
LIMK1 |
Cytoskeleton |
12 |
16 |
| 407 |
kb NB 142-70 |
NA |
PKD |
Other, kinases |
9 |
3 |
| 408 |
Sphingosine Kinase 1 Inhibitor II |
PF-543 |
Sphingosine Kinase |
Other, kinases |
0 |
0 |
| 409 |
eEF2K Inhibitor, A-484954 |
NA |
eEF2K |
Other, kinases |
0 |
0 |
| 410 |
MetAP2 Inhibitor, A832234 |
NA |
MetAP2 |
Other |
3 |
8 |
| 412 |
Venotoclax |
ABT-199, Veneclexta, GDC-0199 |
BCL-2 selective |
Apoptosis regulation |
37 |
8 |
| 415 |
CPI-613 |
NA |
Metabo, Mitochondria |
Other |
0 |
1 |
| 416 |
CAY10566 |
NA |
Stearoyl-CoA desaturase |
Other |
9 |
29 |
| 427 |
Ara-G |
9-??-D-Arabinofuranosyl guanine |
Anti-metabolite |
Other |
187 |
107 |
| 428 |
Pemetrexed |
NA |
TYMS |
DNA replication |
10 |
29 |
| 431 |
Alisertib |
MLN8237 |
AURKA |
Mitosis |
28 |
13 |
| 432 |
Flavopiridol |
NA |
CDK |
Cell cycle |
3 |
5 |
| 435 |
C-75 |
NA |
FAS |
Apoptosis regulation |
21 |
9 |
| 436 |
CAP-232, TT-232, TLN-232 |
NA |
Glycolysis |
Metabolism |
0 |
1 |
| 437 |
Trichostatin A |
NA |
HDAC |
Chromatin histone acetylation |
1 |
17 |
| 438 |
Panobinostat |
Farydak, LBH589 |
HDAC |
Chromatin histone acetylation |
1 |
84 |
| 439 |
LCL161 |
NA |
XIAP, cIAP1, cIAP2 |
Apoptosis regulation |
0 |
4 |
| 442 |
IMD-0354 |
NA |
IKKb |
Other, kinases |
1 |
6 |
| 446 |
MIM1 |
NA |
MCL-1 |
Apoptosis regulation |
4 |
1 |
| 447 |
ETP-45835 |
NA |
MNK1, MNK2 |
Other, kinases |
0 |
0 |
| 449 |
CD532 |
NA |
AURKA |
Mitosis |
34 |
7 |
| 461 |
NSC319726 |
NA |
P53 Mut specific |
p53 pathway |
14 |
13 |
| 474 |
ARRY-520 |
NA |
KIF11 |
Mitosis |
3 |
0 |
| 476 |
SB505124 |
SB 505124, SB505124 |
TGFBR1, ACVR1B, ACVR1C |
RTK signaling |
0 |
5 |
| 477 |
A-83-01 |
NA |
TGFB |
Other |
15 |
6 |
| 478 |
LDN-193189 |
NA |
BMP |
Other |
2 |
19 |
| 546 |
FTY-720 |
Fingolimod hydrochloride; Gilenya; TDI-132; Imusera; Gilenia |
S1P |
Other |
0 |
11 |
| 552 |
BAM7 |
NA |
Bax activator |
Other |
18 |
9 |
| 562 |
AGI-6780 |
NA |
IDH2(R140Q) |
Metabolism |
0 |
0 |
| 563 |
Kobe2602 |
NA |
RAS effector |
RTK signaling |
5 |
7 |
| 573 |
LGK974 |
NA |
PORCN |
WNT signaling |
12 |
7 |
| 574 |
Wnt-C59 |
NA |
PORCN |
WNT signaling |
13 |
48 |
| 576 |
RU-SKI 43 |
NA |
Shh |
Other |
57 |
90 |
| 1001 |
AICA Ribonucleotide |
AICAR, N1-(b-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide |
AMPK agonist |
Metabolism |
16 |
2 |
| 1003 |
Camptothecin |
Camptothecine, (+)-Camptothecin |
TOP1 |
DNA replication |
0 |
0 |
| 1004 |
Vinblastine |
Velban |
Microtubule destabiliser |
Mitosis |
0 |
2 |
| 1005 |
Cisplatin |
cis-Diammineplatinum(II) dichloride, Platinol, CIS-DDP |
DNA crosslinker |
DNA replication |
0 |
1 |
| 1006 |
Cytarabine |
Ara-Cytidine, Arabinosyl Cytosine, U-19920 |
Antimetabolite |
Other |
0 |
0 |
| 1007 |
Docetaxel |
RP-56976, Taxotere |
Microtubule stabiliser |
Mitosis |
0 |
0 |
| 1008 |
Methotrexate |
Abitrexate, Amethopterin, Rheumatrex, Trexall, Folex |
Antimetabolite |
DNA replication |
83 |
54 |
| 1009 |
Tretinoin |
ATRA, Vesanoid, Renova, Atralin, Tretin-X, Avita |
Retinoic acid |
Other |
32 |
8 |
| 1010 |
Gefitinib |
ZD-1839, Iressa |
EGFR |
EGFR signaling |
9 |
7 |
| 1011 |
Navitoclax |
ABT-263, ABT263, ABT 263 |
BCL2, BCL-XL, BCL-W |
Apoptosis regulation |
84 |
4 |
| 1012 |
Vorinostat |
Zolinza, SAHA, suberanilohydroxamic acid, suberoylanilide hydroxamic acid, MK-0683 |
HDAC inhibitor Class I, IIa, IIb, IV |
Chromatin histone acetylation |
39 |
3 |
| 1013 |
Nilotinib |
Tasigna, AMN 107 |
ABL |
ABL signaling |
223 |
43 |
| 1014 |
Refametinib |
RDEA119, BAY-86-9766, BAY 869766 |
MEK1, MEK2 |
ERK MAPK signaling |
5 |
3 |
| 1015 |
CI-1040 |
CI 1040, PD-18435, PD-184352, 212631-79-3 |
MEK1, MEK2 |
ERK MAPK signaling |
2 |
2 |
| 1016 |
Temsirolimus |
CCI-779, Torisel |
MTOR |
PI3K/MTOR signaling |
0 |
9 |
| 1017 |
Olaparib |
AZD2281, KU0059436, Lynparza |
PARP1, PARP2 |
Genome integrity |
69 |
11 |
| 1018 |
Veliparib |
ABT-888, ABT888, ABT 888 |
PARP1, PARP2 |
Genome integrity |
0 |
0 |
| 1019 |
Bosutinib |
SKI-606, Bosulif |
SRC, ABL, TEC |
Other, kinases |
0 |
8 |
| 1020 |
Lenalidomide |
CDC-501, CC-5013, Revlimid |
CRBN |
Protein stability and degradation |
0 |
0 |
| 1021 |
Axitinib |
AG-13736, Inlyta |
PDGFR, KIT, VEGFR |
RTK signaling |
17 |
14 |
| 1022 |
AZD7762 |
AZD-7762, AZD 7762 |
CHEK1, CHEK2 |
Cell cycle |
5 |
3 |
| 1023 |
GW441756 |
GW 441756 |
NTRK1 |
RTK signaling |
5 |
11 |
| 1024 |
Lestaurtinib |
CEP-701, SP-924, SPM-924, A-154475, KT-555 |
FLT3, JAK2, NTRK1, NTRK2, NTRK3 |
Other, kinases |
1 |
6 |
| 1025 |
SB216763 |
SB-216763, SB 216763 |
GSK3A, GSK3B |
WNT signaling |
6 |
2 |
| 1026 |
Tanespimycin |
17-AAG, BMS-722782 |
HSP90 |
Protein stability and degradation |
0 |
0 |
| 1028 |
VX-702 |
VX702, VX 702 |
p38 |
JNK and p38 signaling |
53 |
11 |
| 1029 |
Motesanib |
AMG-706, AMG 706, AMG706 |
VEGFR, RET, KIT, PDGFR |
RTK signaling |
4 |
7 |
| 1030 |
KU-55933 |
KU55933 |
ATM |
Genome integrity |
33 |
25 |
| 1031 |
Elesclomol |
STA-4783 |
HSP90 |
Protein stability and degradation |
0 |
7 |
| 1032 |
Afatinib |
BIBW2992, Tovok, Gilotrif |
ERBB2, EGFR |
EGFR signaling |
0 |
6 |
| 1033 |
Vismodegib |
GDC0449, Erivedge |
SMO |
Other |
0 |
0 |
| 1034 |
Staurosporine |
NA |
Broad spectrum kinase inhibitor |
RTK signaling |
0 |
0 |
| 1036 |
PLX-4720 |
PLX4720, PLX 4720 |
BRAF |
ERK MAPK signaling |
46 |
10 |
| 1037 |
BX795 |
BX-795 |
TBK1, PDK1 (PDPK1), IKK, AURKB, AURKC |
Other, kinases |
1 |
1 |
| 1038 |
NU7441 |
KU-57788, NU-7432, NU-7741 |
DNAPK |
Genome integrity |
49 |
53 |
| 1039 |
SL0101 |
SL-0101, SL 0101-1 |
RSK, AURKB, PIM1, PIM3 |
Other, kinases |
0 |
0 |
| 1042 |
Doramapimod |
BIRB-796, BIRB 796 |
p38, JNK2 |
JNK and p38 signaling |
11 |
7 |
| 1043 |
JNK Inhibitor VIII |
NA |
JNK |
JNK and p38 signaling |
15 |
1 |
| 1046 |
Wee1 Inhibitor |
681640, Wee1 Inhibitor |
WEE1, CHEK1 |
Cell cycle |
0 |
1 |
| 1047 |
Nutlin-3a (-) |
NA |
MDM2 |
p53 pathway |
4 |
8 |
| 1048 |
Mirin |
NA |
MRE11 |
Genome integrity |
11 |
1 |
| 1049 |
PD173074 |
PD-173074, PD 173074 |
FGFR1, FGFR2, FGFR3 |
RTK signaling |
4 |
7 |
| 1050 |
ZM447439 |
ZM-447439, ZM 447439 |
AURKA, AURKB |
Mitosis |
47 |
21 |
| 1051 |
Alisertib |
MLN8237 |
AURKA |
Mitosis |
0 |
0 |
| 1052 |
RO-3306 |
NA |
CDK1 |
Cell cycle |
11 |
8 |
| 1053 |
MK-2206 |
MK 2206, MK2206 |
AKT1, AKT2 |
PI3K/MTOR signaling |
2 |
6 |
| 1054 |
Palbociclib |
PD0332991, PD-0332991, PF-00080665-73 |
CDK4, CDK6 |
Cell cycle |
0 |
3 |
| 1057 |
Dactolisib |
NVP-BEZ235, BEZ235 |
PI3K (class 1), MTORC1, MTORC2 |
PI3K/MTOR signaling |
0 |
7 |
| 1058 |
Pictilisib |
GDC-0941, GDC0941, RG-7621 |
PI3K (class 1) |
PI3K/MTOR signaling |
0 |
0 |
| 1059 |
AZD8055 |
AZD-8055 |
MTORC1, MTORC2 |
PI3K/MTOR signaling |
3 |
1 |
| 1060 |
PD0325901 |
PD-0325901, PD 0325901 |
MEK1, MEK2 |
ERK MAPK signaling |
2 |
8 |
| 1061 |
SB590885 |
SB-590885 |
BRAF |
ERK MAPK signaling |
80 |
13 |
| 1062 |
Selumetinib |
AZD6244, AZD-6244, ARRY-886 |
MEK1, MEK2 |
ERK MAPK signaling |
3 |
9 |
| 1066 |
AZD6482 |
AZD 6482, AZD-6482, AK-55409 |
PI3Kbeta |
PI3K/MTOR signaling |
0 |
1 |
| 1067 |
CCT007093 |
NA |
PPM1D |
Cell cycle |
0 |
0 |
| 1068 |
Obatoclax Mesylate |
GX15-070MS, Obatoclax, GX15-070 |
BCL2, BCL-XL, BCL-W, MCL1 |
Apoptosis regulation |
0 |
0 |
| 1069 |
EHT-1864 |
EHT 1864 |
RAC1, RAC2, RAC3 |
Cytoskeleton |
1 |
11 |
| 1072 |
Avagacestat |
BMS-708163, BMS 708163 |
Amyloid beta20, Amyloid beta40 |
Other |
13 |
4 |
| 1073 |
5-Fluorouracil |
5-FU |
Antimetabolite (DNA & RNA) |
Other |
0 |
0 |
| 1079 |
Dasatinib |
BMS-354825-03, BMS-354825, Sprycel |
ABL, SRC, Ephrins, PDGFR, KIT |
Other, kinases |
0 |
0 |
| 1080 |
Paclitaxel |
BMS-181339-01, Taxol, Onxol, Paxene, Praxel, Abraxane |
Microtubule stabiliser |
Mitosis |
0 |
0 |
| 1083 |
Crizotinib |
Xalkori, PF2341066, PF-2341066, PF 2341066 |
MET, ALK, ROS1 |
RTK signaling |
0 |
0 |
| 1084 |
Rapamycin |
AY-22989, Sirolimus, WY-090217, Torisel, Rapamune |
MTORC1 |
PI3K/MTOR signaling |
0 |
0 |
| 1085 |
Sorafenib |
Nexavar, 284461-73-0, BAY 43-9006 |
PDGFR, KIT, VEGFR, RAF |
Other, kinases |
0 |
0 |
| 1086 |
BI-2536 |
NA |
PLK1, PLK2, PLK3 |
Cell cycle |
0 |
0 |
| 1088 |
Irinotecan |
Camptosar, (+)-Irinotecan, Irinotecanum, irinotecan hydrochloride |
TOP1 |
DNA replication |
0 |
0 |
| 1089 |
Oxaliplatin |
Eloxatin |
DNA alkylating agent |
DNA replication |
0 |
0 |
| 1091 |
BMS-536924 |
BMS 536924 |
IGF1R, IR |
IGF1R signaling |
0 |
0 |
| 1093 |
GSK1904529A |
GSK-1904529A, GSK 1904529A |
IGF1R, IR |
IGF1R signaling |
0 |
0 |
| 1096 |
Tozasertib |
MK 0457,MK-0457,MK-045, VX-680 VX 680 VX-68 |
AURKA, AURKB, AURKC, others |
Mitosis |
0 |
0 |
| 1114 |
Cetuximab |
Erbitux, IMC-C225, C225, IMC-225, L01XC06 |
EGFR |
EGFR signaling |
33 |
40 |
| 1129 |
PF-4708671 |
PF 4708671, PF4708671 |
S6K1 |
PI3K/MTOR signaling |
1 |
5 |
| 1131 |
PRIMA-1MET |
Prima 1MET, APR-246 |
TP53 activation |
p53 pathway |
0 |
0 |
| 1133 |
Serdemetan |
JNJ-26854165 |
MDM2 |
p53 pathway |
0 |
0 |
| 1135 |
AZD4547 |
AZ6 |
FGRF1, FGFR2, FGFR3 |
RTK signaling |
0 |
3 |
| 1136 |
Capivasertib |
AZ5363 |
AKT |
PI3K/MTOR signaling |
2 |
1 |
| 1142 |
HG-5-113-01 |
NA |
LOK, LTK, TRCB, ABL(T315I) |
Other |
0 |
18 |
| 1143 |
HG-5-88-01 |
NA |
EGFR, ADCK4 |
Other, kinases |
0 |
2 |
| 1149 |
TW 37 |
TW37, TW-37 |
BCL2, BCL-XL, MCL1 |
Apoptosis regulation |
0 |
22 |
| 1158 |
XMD11-85h |
NA |
BRSK2, FLT4, MARK4, PRKCD, RET, SRPK1 |
Other, kinases |
22 |
11 |
| 1161 |
ZG-10 |
NA |
JNK1 |
JNK and p38 signaling |
1 |
16 |
| 1164 |
XMD8-92 |
XMD 8-92 |
MAPK7 |
ERK MAPK signaling |
0 |
1 |
| 1166 |
QL-VIII-58 |
NA |
MTOR, ATR |
Other |
0 |
0 |
| 1168 |
Erlotinib |
Tarceva, RG-1415, CP-358774, OSI-774, Ro-508231, R-1415 |
EGFR |
EGFR signaling |
0 |
0 |
| 1170 |
CCT-018159 |
CCT018159, CCT 018159 |
HSP90 |
Protein stability and degradation |
0 |
14 |
| 1175 |
Rucaparib |
PF-01367338, AG-014699, AG-14447, AG-14699 |
PARP1, PARP2 |
Genome integrity |
16 |
6 |
| 1177 |
Niraparib |
MK-4827, MK4827 |
PARP1, PARP2 |
Genome integrity |
0 |
0 |
| 1179 |
MK-1775 |
AZD1775 |
WEE1, PLK1 |
Cell cycle |
0 |
0 |
| 1180 |
Dinaciclib |
SCH727965, SCH 727965, SCH-727-965, MK-7965 |
CDK1, CDK2, CDK5, CDK9 |
Cell cycle |
0 |
0 |
| 1184 |
AZ20 |
NA |
ATR |
Genome integrity |
0 |
3 |
| 1185 |
KU-60019 |
NA |
ATM |
Genome integrity |
2 |
20 |
| 1190 |
Gemcitabine |
Gemzar, LY-188011 |
Pyrimidine antimetabolite |
DNA replication |
0 |
0 |
| 1191 |
Bortezomib |
PS-341, LDP-341, Velcade |
Proteasome |
Protein stability and degradation |
0 |
0 |
| 1192 |
GSK269962A |
GSK 269962A |
ROCK1, ROCK2 |
Cytoskeleton |
0 |
1 |
| 1194 |
SB505124 |
SB 505124, SB505124 |
TGFBR1, ACVR1B, ACVR1C |
RTK signaling |
4 |
27 |
| 1199 |
Tamoxifen |
Nolvadex, Soltamox, Zynoplex, ICI-46474, Kessar |
ESR1 |
Hormone-related |
0 |
0 |
| 1200 |
Fulvestrant |
Faslodex, ICI-182780 |
ESR |
Hormone-related |
0 |
0 |
| 1203 |
QL-XII-61 |
NA |
BMX, BTK |
Other, kinases |
33 |
7 |
| 1218 |
JQ1 |
JQ-1, (+)-JQ-1 |
BRD2, BRD3, BRD4, BRDT |
Chromatin other |
28 |
18 |
| 1219 |
PFI-1 |
NA |
BRD4 |
Chromatin other |
1 |
2 |
| 1230 |
IOX2 |
IOX-2, IOX 2, AK176060 |
EGLN1 |
Other |
14 |
7 |
| 1236 |
UNC0638 |
UNC-0638, UNC 0683 |
G9a and GLP methyltransferases |
Chromatin histone methylation |
0 |
0 |
| 1237 |
EPZ004777 |
EPZ-004777 |
DOT1L |
Chromatin histone methylation |
0 |
0 |
| 1239 |
YK-4-279 |
YK 4-279 |
RNA helicase A |
Other |
0 |
0 |
| 1241 |
CHIR-99021 |
CT 99021, CHIR99021, CHIR 99021 |
GSK3A, GSK3B |
WNT signaling |
0 |
1 |
| 1242 |
(5Z)-7-Oxozeaenol |
5Z-7-Oxozeaenol, LL-Z1640-2 |
TAK1 |
Other, kinases |
2 |
57 |
| 1243 |
Piperlongumine |
Piplartine |
Induces reactive oxygen species |
Other |
0 |
24 |
| 1248 |
Daporinad |
APO866, FK866, FK866 |
NAMPT |
Metabolism |
8 |
0 |
| 1249 |
BMS-345541 |
NA |
IKK-1, IKK-2 |
Other |
0 |
0 |
| 1250 |
AZ960 |
AZ 960, AZ-960 |
JAK2, JAK3 |
Other, kinases |
0 |
0 |
| 1259 |
Talazoparib |
BMN-673, BMN 973 |
PARP1, PARP2 |
Genome integrity |
0 |
2 |
| 1261 |
rTRAIL |
NA |
TRAIL receptor agonist |
Apoptosis regulation |
0 |
3 |
| 1262 |
UNC1215 |
UNC-1215 |
L3MBTL3 |
Chromatin other |
0 |
0 |
| 1263 |
UNC0642 |
NA |
G9a(EHMT2), GLP(EHMT1) |
Chromatin histone methylation |
0 |
0 |
| 1264 |
SGC0946 |
NA |
DOT1L |
Chromatin histone methylation |
0 |
0 |
| 1266 |
ICL1100013 |
NA |
N-myristoyltransferase 1/2 |
Other |
0 |
0 |
| 1268 |
XAV939 |
NVP-XAV939, XAV-939, XAV 939 |
TNKS1, TNKS2 |
WNT signaling |
7 |
9 |
| 1371 |
PLX-4720 |
PLX4720, PLX 4720 |
BRAF |
ERK MAPK signaling |
77 |
6 |
| 1372 |
Trametinib |
GSK1120212, Mekinist |
MEK1, MEK2 |
ERK MAPK signaling |
3 |
6 |
| 1373 |
Dabrafenib |
GSK2118436, Tafinlar |
BRAF |
ERK MAPK signaling |
29 |
6 |
| 1375 |
Temozolomide |
Temodar, Temodal, M-39831, SCH 52365 |
DNA alkylating agent |
DNA replication |
0 |
0 |
| 1377 |
Afatinib |
BIBW2992, Tovok, Gilotrif |
ERBB2, EGFR |
EGFR signaling |
3 |
1 |
| 1378 |
Bleomycin (50 uM) |
NA |
dsDNA break induction |
DNA replication |
0 |
5 |
| 1382 |
AZD3514 |
SN1019841295 |
AR |
Hormone-related |
7 |
7 |
| 1386 |
Doxorubicin |
NA |
Anthracycline |
DNA replication |
0 |
8 |
| 1392 |
Bleomycin (10 uM) |
NA |
dsDNA break induction |
DNA replication |
0 |
2 |
| 1393 |
Gemcitabine |
NA |
Pyrimidine antimetabolite |
DNA replication |
0 |
2 |
| 1394 |
AZD6738 |
SN1034081770 |
ATR |
Genome integrity |
0 |
0 |
| 1401 |
AZD5438 |
SN1057898678 |
CDK2 |
Cell cycle |
0 |
37 |
| 1402 |
AZD7762 |
SN1031853762 |
CHEK1, CHEK2 |
Cell cycle |
0 |
25 |
| 1403 |
AZD6094 |
SN1042487586 |
MET |
RTK signaling |
18 |
2 |
| 1407 |
Dyrk1b_0191 |
SN1008982787 |
DYRK1B |
Other, kinases |
0 |
6 |
| 1409 |
AZD4877 |
SN1055467765 |
EG5 |
Mitosis |
0 |
23 |
| 1413 |
EphB4_9721 |
SN1076287848 |
EPHB4 |
RTK signaling |
0 |
6 |
| 1414 |
Fulvestrant |
SN0117217688 |
ESR1 |
Hormone-related |
5 |
94 |
| 1416 |
AZD8931 |
SN0216062465 |
EGFR, ERBB2, ERBB3 |
RTK signaling |
6 |
0 |
| 1419 |
FEN1_3940 |
SN1106019609 |
FEN1 |
Genome integrity |
0 |
3 |
| 1421 |
FGFR_0939 |
SN1043317881 |
FGFR4 |
RTK signaling |
1 |
9 |
| 1422 |
FGFR_3831 |
SN1037992934 |
FGFR1, FGFR2, FGFR3, FGFR4 |
RTK signaling |
1 |
3 |
| 1425 |
BPTES |
SN1041594574 |
GLS |
Other |
2 |
7 |
| 1426 |
AZD7969 |
SN1098976045 |
GSK3B |
WNT signaling |
0 |
4 |
| 1427 |
AZD5582 |
SN1021632995 |
IAP |
Other |
0 |
0 |
| 1428 |
IAP_5620 |
SN1043546339 |
IAP |
Other |
1 |
1 |
| 1429 |
IAP_7638 |
SN1043547481 |
IAP |
Other |
2 |
3 |
| 1430 |
IGFR_3801 |
SN1056768819 |
IGFR1 |
IGF1R signaling |
0 |
120 |
| 1432 |
AZD1480 |
SN1044232195 |
JAK1, JAK2 |
Other, kinases |
0 |
0 |
| 1433 |
JAK1_3715 |
SN1042605297 |
JAK1 |
Other, kinases |
66 |
3 |
| 1434 |
JAK3_7406 |
SN1014281280 |
JAK3 |
Other, kinases |
0 |
7 |
| 1436 |
MCT1_6447 |
SN0177231247 |
MCT1 |
Cell cycle |
20 |
5 |
| 1437 |
MCT4_1422 |
SN1043999849 |
MCT4 |
Other |
15 |
8 |
| 1441 |
AZD2014 |
SN1103949359 |
mTORC1, mTORC2 |
PI3K/MTOR signaling |
0 |
87 |
| 1444 |
AZD8186 |
SN1028722848 |
PI3Kbeta, PI3Kdelta |
PI3K/MTOR signaling |
1 |
6 |
| 1445 |
AZD8835 |
SN1040214596 |
PI3Kalpha, PI3Kdelta |
PI3K/MTOR signaling |
0 |
2 |
| 1446 |
PI3Ka_4409 |
SN1037097676 |
PI3Kalpha, PI3Kdelta |
PI3K/MTOR signaling |
3 |
2 |
| 1449 |
AZD1208 |
SN1028350371 |
PIM1, PIM2, PIM3 |
Other, kinases |
3 |
11 |
| 1451 |
PLK_6522 |
SN1077317349 |
PLK1, PLK2, PLK3 |
Cell cycle |
0 |
8 |
| 1453 |
RAF_9304 |
SN1034259943 |
ARAF, BRAF, CRAF |
ERK MAPK signaling |
2 |
1 |
| 1458 |
PARP_9495 |
SN1024601395 |
PARP1, PARP2, PARP7 |
Genome integrity |
0 |
2 |
| 1459 |
PARP_0108 |
SN1044053371 |
PARP1, PARP2, PARP6 |
Genome integrity |
0 |
1 |
| 1460 |
PARP_9482 |
SN1031920820 |
PARP1, PARP2, PARP5a |
Genome integrity |
0 |
5 |
| 1461 |
TANK_1366 |
SN1032446568 |
Tankyrase 1/2 (PARP5a, PARP5b) |
Genome integrity |
14 |
7 |
| 1463 |
AZD1332 |
SN1061387896 |
NTRK1, NTRK2, NTRK3 |
RTK signaling |
2 |
11 |
| 1464 |
TTK_3146 |
SN1080714093 |
TTK |
Mitosis |
0 |
2 |
| 1490 |
SN-38 |
SN1095903706 |
TOP1 |
DNA replication |
0 |
2 |
| 1494 |
SN-38 |
7-Ethyl-10-Hydroxy-Camptothecin, SN 38 |
TOP1 |
DNA replication |
0 |
9 |
| 1495 |
Olaparib |
AZD2281, KU0059436, Lynparza |
PARP1, PARP2 |
Genome integrity |
4 |
14 |
| 1496 |
Cisplatin |
Cisplatin |
DNA crosslinker |
DNA replication |
4 |
2 |
| 1497 |
AZD4547 |
AZ6 |
FGFR1, FGFR2, FGFR3 |
RTK signaling |
9 |
8 |
| 1498 |
Selumetinib |
AZD6244, AZD-6244, ARRY-886 |
MEK1, MEK2 |
ERK MAPK signaling |
6 |
3 |
| 1502 |
Bicalutamide |
ICI-176334, Casodex, Cosudex, ICI 176334 |
AR |
Hormone-related |
0 |
0 |
| 1507 |
Ruxolitinib |
INCB-18424, Ruxolitinib Phosphate, Jakafi |
JAK1, JAK2 |
Other, kinases |
0 |
0 |
| 1510 |
Linsitinib |
OSI-906, ASP-7487 |
IGF1R |
IGF1R signaling |
0 |
0 |
| 1511 |
Epirubicin |
Ellence, Farmorubicin, IMI-28 |
Anthracycline |
DNA replication |
0 |
0 |
| 1512 |
Cyclophosphamide |
Cytoxan, Neosar, Cyclophosphamid, Procytox, Cyclophosphane |
Alkylating agent |
DNA replication |
0 |
0 |
| 1526 |
Refametinib |
RDEA119, BAY-86-9766, BAY 869766 |
MEK1, MEK2 |
ERK MAPK signaling |
3 |
3 |
| 1527 |
Pictilisib |
GDC-0941, GDC0941, RG-7621 |
PI3K (class 1) |
PI3K/MTOR signaling |
0 |
2 |
| 1529 |
Pevonedistat |
MLN4924, MLN 4924, MLN-4924 |
NAE |
Other |
0 |
1 |
| 1530 |
PFI-3 |
BDF00016096 |
SMARCA2, SMARCA4, PB1 |
Chromatin other |
0 |
0 |
| 1549 |
Sapitinib |
AZD8931 |
EGFR, ERBB2, ERBB3 |
EGFR signaling |
0 |
0 |
| 1553 |
Uprosertib |
GSK2141795, GSK2141795C, GSK-2141795 |
AKT1, AKT2, AKT3 |
PI3K/MTOR signaling |
0 |
0 |
| 1557 |
LCL161 |
NA |
XIAP, IAP1, IAP2 |
Apoptosis regulation |
0 |
0 |
| 1558 |
Lapatinib |
Tykerb, Tyverb |
EGFR, ERBB2 |
EGFR signaling |
0 |
0 |
| 1559 |
Luminespib |
AUY922, VER-52296,NVP-AUY922, AUY |
HSP90 |
Protein stability and degradation |
0 |
0 |
| 1560 |
Alpelisib |
BYL719, BYL-719, NVP-BYL719 |
PI3Kalpha |
PI3K/MTOR signaling |
0 |
0 |
| 1561 |
Taselisib |
GDC-0032, GDC0032, RG7604 |
PI3K (beta sparing) |
PI3K/MTOR signaling |
0 |
0 |
| 1563 |
EPZ5676 |
EPZ-5676, Pinometostat |
DOT1L |
Chromatin histone methylation |
0 |
0 |
| 1564 |
SCH772984 |
CS-1421 |
ERK1, ERK2 |
ERK MAPK signaling |
0 |
0 |
| 1576 |
IWP-2 |
Wnt Inhibitor IWP-2 |
PORCN |
WNT signaling |
0 |
0 |
| 1578 |
Leflunomide |
Sulol, SU-101, HWA-486, Arava |
Pyrimidine synthesis inhibitor |
DNA replication |
0 |
0 |
| 1593 |
Entinostat |
MS-275 |
HDAC1, HDAC3 |
Chromatin histone acetylation |
0 |
0 |
| 1594 |
OSI-027 |
A-1065-5 |
MTORC1, MTORC2 |
PI3K/MTOR signaling |
0 |
0 |
| 1598 |
LGK974 |
LGK-974 |
PORCN |
WNT signaling |
0 |
0 |
| 1613 |
VE-822 |
VE 822, VE822, Berzosertib |
ATR |
Genome integrity |
0 |
0 |
| 1614 |
WZ4003 |
WZ 4003 |
NUAK1, NUAK2 |
Other, kinases |
0 |
0 |
| 1615 |
CZC24832 |
GTPL6653 |
PI3Kgamma |
PI3K/MTOR signaling |
0 |
0 |
| 1617 |
AZD5582 |
GTPL7710, AOB5560 |
XIAP, cIAP |
Apoptosis regulation |
0 |
0 |
| 1618 |
GSK2606414 |
AK175551 |
PERK |
Metabolism |
0 |
0 |
| 1620 |
PFI3 |
PFI-3, PFI 3, AOB2221 |
Polybromo 1, SMARCA4, SMARCA2 |
Chromatin other |
0 |
0 |
| 1621 |
PCI-34051 |
AK298746 |
HDAC8, HDAC6, HDAC1 |
Chromatin histone acetylation |
0 |
0 |
| 1622 |
Wnt-C59 |
AOB3540, AK161197 |
PORCN |
WNT signaling |
0 |
0 |
| 1624 |
I-BET-762 |
GSK525762A |
BRD2, BRD3, BRD4 |
Chromatin other |
0 |
0 |
| 1625 |
RVX-208 |
1044870-39-4, Apabetalone |
BRD4 |
Chromatin other |
0 |
0 |
| 1626 |
OTX015 |
Birabresib, OTX-015, MK-8628 |
BRD2, BRD3, BRD4 |
Chromatin other |
0 |
0 |
| 1627 |
GSK343 |
GTPL8240, AOB3680, AK175558 |
EZH2 |
Chromatin histone methylation |
0 |
0 |
| 1629 |
ML323 |
GTPL7898, AOB2313, |
USP1, UAF1 |
Protein stability and degradation |
0 |
0 |
| 1630 |
Entospletinib |
GS-9973 |
SYK |
Other, kinases |
0 |
0 |
| 1631 |
PRT062607 |
P505-15, PRT-2607, BIIB-057 |
SYK |
Other, kinases |
0 |
0 |
| 1632 |
Ribociclib |
LEE011, NVP-LEE011, LEE011-BBA |
CDK4, CDK6 |
Cell cycle |
0 |
0 |
| 1634 |
AGI-6780 |
AK162157 |
IDH2 R140Q mutant |
Metabolism |
0 |
0 |
| 1635 |
Picolinici-acid |
Picolinate |
Inflammatory related |
Other |
0 |
0 |
| 1706 |
AZD5153 |
SN1045566955, AZD5153 |
BRD4 |
Chromatin other |
0 |
0 |
| 1708 |
CDK9_5576 |
SN1047226266, CDK9_5576 |
CDK9 |
Cell cycle |
0 |
0 |
| 1709 |
CDK9_5038 |
SN1047483750, CDK9_5038 |
CDK9 |
Cell cycle |
0 |
0 |
| 1712 |
Eg5_9814 |
SN1047613775, Eg5_9814 |
KSP11 |
Other |
0 |
0 |
| 1713 |
ERK_2440 |
SN1051032892, ERK_2440 |
ERK1,ERK2 |
ERK MAPK signaling |
0 |
0 |
| 1714 |
ERK_6604 |
SN1047587618, ERK_6604 |
ERK1,ERK2 |
ERK MAPK signaling |
0 |
0 |
| 1716 |
IRAK4_4710 |
SN1050852374, IRAK4_4710 |
IRAK4 |
Other, kinases |
0 |
0 |
| 1718 |
JAK1_8709 |
SN1049200060, JAK1_8709 |
JAK1 |
Other, kinases |
0 |
0 |
| 1720 |
AZD5991 |
SN1049446612, AZD5991 |
MCL1 |
Apoptosis regulation |
0 |
0 |
| 1730 |
PAK_5339 |
SN1046290829, PAK_5339 |
PAK1, PAK2 |
Cytoskeleton |
0 |
0 |
| 1732 |
TAF1_5496 |
SN1050393042, TAF1_5496 |
TAF1 |
Other |
0 |
0 |
| 1733 |
ULK1_4989 |
SN1049257073, ULK1_4989 |
ULK1 |
Other, kinases |
0 |
0 |
| 1734 |
VSP34_8731 |
SN1049998399, VSP34_8731 |
VSP34 |
Other |
0 |
0 |
| 1736 |
Selumetinib |
SN1103949345, AZD1480 |
MEK1, MEK2 |
ERK MAPK signaling |
0 |
0 |
| 1738 |
IGF1R_3801 |
SN1051640224, IGF1R_3801 |
IGFR1 |
IGF1R signaling |
0 |
0 |
| 1739 |
JAK_8517 |
SN1066590414, JAK_8517 |
JAK1, JAK2 |
Other, kinases |
0 |
0 |
| 1786 |
AZD4547 |
1035270-39-3 |
FGFR1, FGFR2, FGFR3 |
RTK signaling |
0 |
0 |
| 1799 |
Ibrutinib |
PCI-32765, CRA-032765, PCI-32765-00 |
BTK |
Other, kinases |
0 |
0 |
| 1802 |
Zoledronate |
Zoledronic acid, Zometa, Reclast |
NA |
Unclassified |
0 |
0 |
| 1804 |
Acetalax |
Oxyphenisatin acetate |
NA |
Unclassified |
0 |
0 |
| 1806 |
Oxaliplatin |
NA |
DNA alkylating agent |
DNA replication |
0 |
0 |
| 1807 |
Carmustine |
NA |
NA |
DNA replication |
0 |
0 |
| 1808 |
Topotecan |
NA |
NA |
DNA replication |
0 |
0 |
| 1809 |
Teniposide |
Vumon |
NA |
DNA replication |
0 |
0 |
| 1810 |
Mitoxantrone |
NA |
NA |
DNA replication |
0 |
0 |
| 1811 |
Dactinomycin |
Actinomycin D |
NA |
Other |
0 |
0 |
| 1813 |
Fludarabine |
Fludara |
NA |
Unclassified |
0 |
0 |
| 1814 |
Nelarabine |
Atriance, Arranon |
NA |
DNA replication |
0 |
0 |
| 1816 |
Fulvestrant |
NA |
NA |
Hormone-related |
0 |
0 |
| 1818 |
Vincristine |
NA |
NA |
Mitosis |
0 |
0 |
| 1819 |
Docetaxel |
RP-56976, Taxotere |
Microtubule stabiliser |
Mitosis |
0 |
0 |
| 1825 |
Podophyllotoxin bromide |
NA |
NA |
Unclassified |
0 |
0 |
| 1827 |
Dihydrorotenone |
NA |
NA |
Unclassified |
0 |
0 |
| 1830 |
Gallibiscoquinazole |
NA |
NA |
Unclassified |
0 |
0 |
| 1835 |
Elephantin |
NA |
NA |
Unclassified |
0 |
0 |
| 1838 |
Sinularin |
NA |
NA |
Unclassified |
0 |
0 |
| 1849 |
Sabutoclax |
BI-97C1 |
BCL2, BCL-XL, BFL1, MCL1 |
Apoptosis regulation |
0 |
0 |
| 1852 |
LY2109761 |
5XE |
TGFB1 |
Other |
0 |
0 |
| 1853 |
OF-1 |
NA |
BRPF1B, BRPF2 |
Chromatin histone acetylation |
0 |
0 |
| 1854 |
MN-64 |
NA |
TNKS1, TNKS2 |
WNT signaling |
0 |
0 |
| 1855 |
KRAS (G12C) Inhibitor-12 |
GTPL8020 |
KRAS (G12C) |
ERK MAPK signaling |
0 |
0 |
| 1862 |
MG-132 |
LLL cpd, MG 132, MG132 |
Proteasome, CAPN1 |
Protein stability and degradation |
0 |
0 |
| 1866 |
BDP-00009066 |
NA |
MRCKB_HUMAN |
Cytoskeleton |
0 |
0 |
| 1873 |
Buparlisib |
BKM120, NVP-BKM120 |
PI3Kalpha, PI3Kdelta, PI3Kbeta, PI3Kgamma |
PI3K/MTOR signaling |
0 |
0 |
| 1908 |
Ulixertinib |
BVD-523, VRT752271 |
ERK1, ERK2 |
ERK MAPK signaling |
0 |
0 |
| 1909 |
Venetoclax |
ABT-199, Veneclexta, GDC-0199 |
BCL2 |
Apoptosis regulation |
0 |
0 |
| 1910 |
ABT737 |
NA |
BCL2, BCL-XL, BCL-W, BCL-B, BFL1 |
Apoptosis regulation |
0 |
0 |
| 1911 |
Dactinomycin |
Actinomycin D, Cosmegen, Lyovac, Meractinomycin, Ac-De, ActD |
RNA polymerase |
Other |
0 |
0 |
| 1912 |
Afuresertib |
GSK2110183, GSK2110183C |
AKT1, AKT2, AKT3 |
PI3K/MTOR signaling |
0 |
0 |
| 1913 |
AGI-5198 |
IDH-C35 |
IDH1 (R132H) |
Metabolism |
0 |
0 |
| 1915 |
AZD3759 |
NA |
EGFR |
EGFR signaling |
0 |
0 |
| 1916 |
AZD5363 |
NA |
AKT1, AKT2, AKT3, ROCK2 |
Other, kinases |
0 |
0 |
| 1917 |
AZD6738 |
AZD 6738, AZD-6738 |
ATR |
Genome integrity |
0 |
0 |
| 1918 |
AZD8186 |
AZD 8186, AZD-8186 |
PI3Kalpha, PI3Kbeta |
PI3K/MTOR signaling |
0 |
0 |
| 1919 |
Osimertinib |
AZD9291, AZD 9291, AZD-9291, Tagrisso, Mereletinib |
EGFR |
EGFR signaling |
0 |
0 |
| 1922 |
Cediranib |
AZD2171, AZD 2171, AZD-2171, Recentin |
VEGFR, FLT1, FLT2, FLT3, FLT4, KIT, PDGFRB |
RTK signaling |
0 |
0 |
| 1924 |
Ipatasertib |
GDC0068, GDC 0068, GDC-0068 |
AKT1, AKT, AKT3 |
PI3K/MTOR signaling |
0 |
0 |
| 1925 |
GDC0810 |
GDC-0810, GDC 0810 |
ESR1, ESR2 |
Hormone-related |
0 |
0 |
| 1926 |
GNE-317 |
GNE317, GNE 317 |
PI3Kalpha |
PI3K/MTOR signaling |
0 |
0 |
| 1927 |
GSK2578215A |
GSK 2578215A, GSK-2578215A |
LRRK2 |
Other, kinases |
0 |
0 |
| 1928 |
I-BRD9 |
GSK602, GSK 602, GSK-602 |
BRD9 |
Chromatin other |
0 |
0 |
| 1930 |
Telomerase Inhibitor IX |
MST-312, MST 312, MST312 |
Telomerase |
Genome integrity |
0 |
0 |
| 1931 |
MIRA-1 |
MIRA 1, MIRA1, NSC19630, NSC-19630, NSC 19630 |
TP53 |
p53 pathway |
0 |
0 |
| 1932 |
NVP-ADW742 |
NVP ADW742, NVPADW742 |
IGF1R |
IGF1R signaling |
0 |
0 |
| 1933 |
P22077 |
P 22077, P-22077 |
USP7, USP47 |
Protein stability and degradation |
0 |
0 |
| 1936 |
Savolitinib |
AZD6094, Volitinib, AZD-6094, AZD 6094 |
MET |
RTK signaling |
0 |
0 |
| 1939 |
UMI-77 |
UMI 77, UMI-77 |
MCL1 |
Apoptosis regulation |
0 |
0 |
| 1940 |
WIKI4 |
WIKI-4, WIKI 4 |
TNKS1, TNKS2 |
WNT signaling |
0 |
0 |
| 1941 |
Sepantronium bromide |
YM155, YM-155, YM 155 |
BIRC5 |
Apoptosis regulation |
0 |
0 |
| 1996 |
MIM1 |
MIM 1, MIM-1 |
MCL1 |
Apoptosis regulation |
0 |
0 |
| 1997 |
WEHI-539 |
WEHI539, WEHI-539 |
BCL-XL |
Apoptosis regulation |
0 |
0 |
| 1998 |
BPD-00008900 |
NA |
NA |
Other |
0 |
0 |
| 2040 |
Foretinib |
GSK1363089, XL-880, EXEL-2880, GSK089 |
MET, KDR, TIE2, VEGFR3/FLT4, RON, PDGFR, FGFR1, EG |
RTK signaling |
0 |
0 |
| 2043 |
BIBR-1532 |
NA |
TERT |
Genome integrity |
0 |
0 |
| 2044 |
Pyridostatin |
NA |
G-quadruplex stabiliser |
DNA replication |
0 |
0 |
| 2045 |
AMG-319 |
AMG319 |
PI3K (beta sparing) |
PI3K/MTOR signaling |
0 |
0 |
| 2046 |
MK-8776 |
SCH900776 |
CHEK1, CHEK2, CDK2 |
Cell cycle |
0 |
0 |
| 2047 |
Ulixertinib |
BVD-523, VRT752271 |
ERK1, ERK2 |
ERK MAPK signaling |
0 |
0 |
| 2048 |
Vinorelbine |
vinorelbine tartrate, Navelbine, Exelbine |
Microtubule destabiliser |
Mitosis |
0 |
0 |
| 2096 |
VX-11e |
VX11e, VX11e |
ERK2 |
ERK MAPK signaling |
0 |
0 |
| 2106 |
Uprosertib |
GSK2141795, GSK2141795C, GSK-2141795 |
AKT1, AKT2, AKT3 |
PI3K/MTOR signaling |
0 |
0 |
| 2107 |
LJI308 |
NA |
RSK2, RSK1, RSK3 |
PI3K/MTOR signaling |
0 |
0 |
| 2109 |
AZ6102 |
NA |
TNKS1, TNKS2 |
WNT signaling |
0 |
0 |
| 2110 |
GSK591 |
EPZ015866, GSK3203591 |
PMRT5 |
Chromatin histone methylation |
0 |
0 |
| 2111 |
VE821 |
VE 821, VE-821 |
ATR |
Genome integrity |
0 |
0 |
| 2169 |
AZD6482 |
AZD 6482, AZD-6482, AK-55409 |
PI3Kbeta |
PI3K/MTOR signaling |
0 |
0 |
| 2170 |
AT13148 |
NA |
AKT1 |
PI3K/MTOR signaling |
0 |
0 |
| 2171 |
BMS-754807 |
BMS-754807 |
IGF1R, IR |
IGF1R signaling |
0 |
0 |
| 2172 |
JQ1 |
JQ-1, (+)-JQ-1 |
BRD2, BRD3, BRD4, BRDT |
Chromatin other |
0 |
0 |